GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7714584 | 1 | rs60134818 | chr5:150261043 | LOC134466 | chr5:150310000-150326146:- | 0.38 | 5.29 | 1.84E-7 | Crohn's disease |
| THCA | cis | rs1144333 | 1 | rs60144605 | chr1:76359699 | ACADM | chr1:76190043-76229353:+ | -0.26 | -5.3 | 1.73E-7 | Attention function in attention deficit hyperactive disorder |
| THCA | cis | rs12216499 | 1 | rs60146975 | chr6:159358206 | RSPH3 | chr6:159398268-159421198:- | 0.26 | 5.49 | 6.43E-8 | Bladder cancer (smoking interaction) |
| THCA | cis | rs6099314 | 1 | rs6014859 | chr20:55454584 | CBLN4 | chr20:54572497-54580012:- | -0.21 | -3.49 | 0.000536 | Chronic obstructive pulmonary disease (moderate to severe) |
| THCA | cis | rs60843830 | 1 | rs60149603 | chr2:285421 | SH3YL1 | chr2:218138-264810:- | -0.94 | -26.08 | 6.91E-94 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs35123781 | 1 | rs601728 | chr5:139057076 | DNAJC18 | chr5:138747381-138775139:- | 0.16 | 3.62 | 0.000321 | Schizophrenia |
| THCA | cis | rs34602589 | 1 | rs6017495 | chr20:43756955 | STK4 | chr20:43595120-43708591:+ | -0.17 | -4.05 | 5.98E-5 | Parental longevity (mother's age at death) |
| THCA | cis | rs1008375 | 1 | rs60178264 | chr4:17685308 | MED28 | chr4:17616273-17629791:+ | 0.16 | 3.43 | 0.000658 | Parasitemia in Tripanosoma cruzi seropositivity |
| THCA | cis | rs3760982 | 1 | rs60184524 | chr19:44294215 | LYPD5 | chr19:44300080-44324808:- | -0.24 | -5.05 | 6.18E-7 | Breast cancer |
| THCA | cis | rs3760982 | 1 | rs60184524 | chr19:44294215 | ZNF155 | chr19:44488355-44502477:+ | -0.25 | -5.66 | 2.58E-8 | Breast cancer |
| THCA | cis | rs3760982 | 1 | rs60184524 | chr19:44294215 | ZNF404 | chr19:44376516-44384288:- | -0.26 | -6.8 | 3.16E-11 | Breast cancer |
| THCA | cis | rs365132 | 1 | rs601923 | chr5:176417386 | ZNF346 | chr5:176449697-176508190:+ | -0.16 | -5.51 | 5.99E-8 | Menopause (age at onset);Menarche and menopause (age at onset) |
| THCA | cis | rs3771570 | 1 | rs60209440 | chr2:242260340 | ANO7 | chr2:242127924-242164791:+ | 0.36 | 4.13 | 4.26E-5 | Prostate cancer |
| THCA | cis | rs3771570 | 1 | rs60209440 | chr2:242260340 | SEPT2 | chr2:242254723-242293439:+ | -0.29 | -4.17 | 3.59E-5 | Prostate cancer |
| THCA | cis | rs8030605 | 1 | rs60210425 | chr15:56494711 | TEX9 | chr15:56657644-56738071:+ | -0.34 | -5.88 | 7.84E-9 | Waist-to-hip ratio adjusted for body mass index |